3-Bromo-1,1,1-trifluoro-2-propanone → 6-Bromo-5-methyl-2-trifluoromethyl-2,3-dihydroimidazo [1,2-a]pyridin-2-ol hydrobromide
반응식
[Br:1][CH2:2][C:3](=[O:8])[C:4]([F:7])([F:6])[F:5].[NH2:9][C:10]1[CH:15]=[CH:14][C:13]([Br:16])=[C:12]([CH3:17])[N:11]=1>COCCOC>[BrH:1].[Br:16][C:13]1[CH:14]=[CH:15][C:10]2[N:11]([CH2:2][C:3]([C:4]([F:7])([F:6])[F:5])([OH:8])[N:9]=2)[C:12]=1[CH3:17]참가 물질
4
실험 절차
A mixture of 1.91 g of 3-bromo-1,1,1-trifluoropropan-2-one and 10 ml of DME was added to a mixture of 1.87 g of 2-amino-5-bromo-6-methylpyridine and 10 ml of DME, and the mixture was stirred at room temperature for 3 hours. The precipitated solid was taken by filtration, washed with 10 ml of DME, and dried to obtain 3.39 g of 6-bromo-5-methyl-2-trifluoromethyl-2,3-dihydroimidazo [1,2-a]pyridin-2-ol hydrobromide.
후처리
- filtrationThe precipitated solid was taken by filtration
- washwashed with 10 ml of DME
- customdried
출처 및 근거
- ORD 기록
- ord-8d56e6f7a3c540fbb7e2f97d51538589
- 출처 데이터셋
- uspto-grants-2016_05
- 특허 번호
- US09328121B1
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