Potassium Cyanide → (1-Oxo-2,3-dihydro-1H-pyrrolizin-2-yl)acetonitrile

반응식

CN([CH2:4][CH:5]1[CH2:12][N:11]2[C:7](=[CH:8][CH:9]=[CH:10]2)[C:6]1=[O:13])C.[C-:14]#[N:15].[K+]>>[C:14]([CH2:4][CH:5]1[CH2:12][N:11]2[C:7](=[CH:8][CH:9]=[CH:10]2)[C:6]1=[O:13])#[N:15]

참가 물질

반응물 2

HCID 9032Potassium Cyanide

HCID 102196682-Dimethylaminomethyl-1, 2-dihydro-1-pyrrolizinone

생성물 1

HCID 54473544(1-Oxo-2,3-dihydro-1H-pyrrolizin-2-yl)acetonitrile수율 68%

반응 조건

온도: 100 °C

실험 절차

To 100 ml H2O0 were added 8.6% of compound 2 and 5.2 g KCN. The solution was gently heated to 100° C. and kept stirring for 10 minutes. After cooling to r.t., the reaction mixture was extracted with CH2CI2 (60×3). Evaporated the solvent, 6 g oil was obtained. Purified by column chromatography on silica gel, 4 g of compound 8 was obtained as white powder, mp 68° C., yield 68%.

후처리

temperatureAfter cooling to r.t.
extractionthe reaction mixture was extracted with CH2CI2 (60×3)
customEvaporated the solvent

출처 및 근거

ORD 기록: ord-785f0cdf06ca404cbfc61e979beadff8
출처 데이터셋: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05616604

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