5-amino-1-phenyl-1H-pyrazole-3-carbonitrile → 5-bromo-2-chloro-N-(3-cyano-1-phenyl-1H-pyrazol-5-yl)-3-fluorobenzamide

HRID 522132노트

반응식

HRID 522132 반응식
[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([C:13]#[N:14])[CH:3]=1.[Br:15][C:16]1[CH:17]=[C:18]([F:26])[C:19]([Cl:25])=[C:20]([CH:24]=1)[C:21](O)=[O:22]>>[Br:15][C:16]1[CH:17]=[C:18]([F:26])[C:19]([Cl:25])=[C:20]([CH:24]=1)[C:21]([NH:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([C:13]#[N:14])[CH:3]=1)=[O:22]

참가 물질

3

반응물 2

HCID 177636545-amino-1-phenyl-1H-pyrazole-3-carbonitrileHCID 814545435-Bromo-2-chloro-3-fluorobenzoic acid

생성물 1

HCID 1184971755-bromo-2-chloro-N-(3-cyano-1-phenyl-1H-pyrazol-5-yl)-3-fluorobenzamide

실험 절차

The title compound was prepared according to the method described for Preparation 16 using 5-amino-1-phenyl-1H-pyrazole-3-carbonitrile (Preparation 53) and 5-bromo-2-chloro-3-fluorobenzoic acid.

출처 및 근거

ORD 기록
ord-c91aa3a9542b4b8b856c5779c78d494d
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09328096B2

반응 노트

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