Methanol → 6-Nitrohexanoic acid methyl ester

HRID 522494

반응식

HRID 522494 반응식
[N+:1]([CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][C:5]1=[O:10])([O-:3])=[O:2].[CH3:11][OH:12]>>[CH3:11][O:12][C:5](=[O:10])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:4][N+:1]([O-:3])=[O:2]

참가 물질

3

반응물 2

HCID 887MethanolHCID 5212412-Nitrocyclohexanone

생성물 1

HCID 110843876-Nitrohexanoic acid methyl ester수율 89%

실험 절차

2-Nitrocyclohexanone (6.77 g; 47.3 mmol) was dissolved in dried MeOH (150 mL) and a two fold excess by weight of Amberlyst® A21 (13.5 g) was added. The mixture was refluxed under nitrogen for 1.5 h then filtered and evaporated to give 6-nitrohexanoic acid methyl ester (7.72 g; 42 mmol). Yield: 89%.

후처리

  1. additiona two fold excess by weight of Amberlyst® A21 (13.5 g) was added
  2. temperatureThe mixture was refluxed under nitrogen for 1.5 h
  3. filtrationthen filtered
  4. customevaporated

출처 및 근거

ORD 기록
ord-53dc520c83e2445aa2a32eb2184eae09
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09333272B2

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