Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dronedarone → 2-Butylbenzofuran-5-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dronedarone | HCID 208898 | — |
| 반응물 | 2-Butyl-5-nitrobenzofuran | HCID 9837358 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Platinum oxide (PtO) | HCID 82844 | — |
| 생성물 | 2-Butylbenzofuran-5-amine | HCID 9813311 | — |
반응 단계
A process for synthesizing dronedarone was described in patent application WO 02/48132, mentioned previously, using 2-n-butyl-5-nitrobenzofuran, which is reduced, under pressure with hydrogen in the presence of platinum oxide as catalyst to form 2-n-butyl-5-aminobenzofuran. This benzofuran derivative is then subjected to the action of methanesulfonyl chloride, which gives 2-n-butyl-5-methanesulfonamidobenzofuran, which is treated with 4-[3-(di-n-butylamino)propoxy]benzoyl chloride to obtain dronedarone.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09334254B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-2f212b1e98fe444a8d6dbe3c7b91b1ad |
| 출처 메모 | uspto-grants-2016_05 |