3,5-Difluoropyridine-4-carbaldehyde → (3,5-Difluoropyridin-4-yl)methanol
반응식
FC1C(CO)=NC=CC=1F.[F:11][C:12]1[CH:13]=[N:14][CH:15]=[C:16]([F:20])[C:17]=1[CH:18]=[O:19]>CO>[F:11][C:12]1[CH:13]=[N:14][CH:15]=[C:16]([F:20])[C:17]=1[CH2:18][OH:19]참가 물질
4
실험 절차
Title compound was prepared by a method analogous to that described for Intermediate 7, replacing 3,4-difluoro-2-pyridinecarbaldehyde with 3,5-difluoro-4-pyridinecarbaldehyde (FRONTIER) and using MeOH as solvent. (200 mg, 1.398 mmol, 73% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm: 8.51 (s, 2H), 5.55 (t, 1H), 4.55-4.57 (m, 2H). [ES+MS] m/z 146 (MH+).
출처 및 근거
- ORD 기록
- ord-58cc3fa1698142de9a9ade3f384750de
- 출처 데이터셋
- uspto-grants-2016_05
- 특허 번호
- US09334265B2
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