Ammonium Carbonate → (4-Nitrophenyl)methanesulfonamide

HRID 522678노트

반응식

HRID 522678 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][S:11](Cl)(=[O:13])=[O:12])=[CH:6][CH:5]=1)([O-:3])=[O:2].C(=O)([O-])[O-].[NH4+:19].[NH4+]>C(#N)C.N>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][S:11]([NH2:19])(=[O:13])=[O:12])=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

5

반응물 2

HCID 517111Ammonium CarbonateHCID 2794642(4-Nitrophenyl)methanesulfonyl chloride

생성물 1

HCID 2755281(4-Nitrophenyl)methanesulfonamide수율 93%

시약·촉매·용매 2

HCID 222Ammonia용매HCID 6342Acetonitrile용매

실험 절차

To a solution of (4-nitrophenyl)methanesulfonyl chloride (4 g, 17 mmol) in acetonitrile (100 mL) was added a solution of ammonium carbonate (3 g, 31.3 mmol) in ammonia (50 mL). The reaction mixture was stirred for 1 h, and TLC indicated the starting material consumed completely. The organic solvent was removed under reduced pressure. Addition of water (10 mL) led to precipitate formation. The solid was collected, washed with water (2×5 mL), and dried to give (4-nitrophenyl)methanesulfonamide (3.4 g, 93%) as a white solid. MS (ES+) C7H8N2O4S requires: 216, found: 217 [M+H]+.

후처리

  1. customconsumed completely
  2. customThe organic solvent was removed under reduced pressure
  3. additionAddition of water (10 mL)
  4. customto precipitate formation
  5. customThe solid was collected
  6. washwashed with water (2×5 mL)
  7. customdried

출처 및 근거

ORD 기록
ord-682bdb71b5c04a29b771059b4eb53331
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09334263B2

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