Cesium carbonate → 6-chloro-5-(3-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3 (4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide

반응식

Br[C:2]1[C:14]([Cl:15])=[CH:13][C:12]([C:16]([NH2:18])=[O:17])=[C:11]2[C:3]=1[C:4]1[CH2:5][CH2:6][C@H:7]([C:19]([OH:22])([CH3:21])[CH3:20])[CH2:8][C:9]=1[NH:10]2.[F:23][C:24]1[CH:25]=[CH:26][CH:27]=[C:28]2[C:33]=1[N:32]([CH3:34])[C:31](=[O:35])[N:30]([C:36]1[CH:41]=[CH:40][CH:39]=[C:38](B3OC(C)(C)C(C)(C)O3)[C:37]=1[CH3:51])[C:29]2=[O:52].C([O-])([O-])=O.[Cs+].[Cs+]>C1COCC1.O.CCOC(C)=O.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].C(Cl)Cl>[Cl:15][C:14]1[C:2]([C:38]2[CH:39]=[CH:40][CH:41]=[C:36]([N:30]3[C:29](=[O:52])[C:28]4[C:33](=[C:24]([F:23])[CH:25]=[CH:26][CH:27]=4)[N:32]([CH3:34])[C:31]3=[O:35])[C:37]=2[CH3:51])=[C:3]2[C:11](=[C:12]([C:16]([NH2:18])=[O:17])[CH:13]=1)[NH:10][C:9]1[CH2:8][C@@H:7]([C:19]([OH:22])([CH3:21])[CH3:20])[CH2:6][CH2:5][C:4]2=1