Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Maleic Anhydride → 4-(Trifluoromethyl)benzohydrazide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Maleic Anhydride | HCID 7923 | — |
| 반응물 | Hydrazine | HCID 9321 | — |
| 반응물 | Cycloheptatriene | HCID 11000 | — |
| 반응물 | Methyl 4-(trifluoromethyl)benzoate | HCID 520447 | — |
| 반응물 | Tecovirimat monohydrate | HCID 90479083 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 용매 | Toluene heptane | HCID 22263336 | — |
| 생성물 | 4-(Trifluoromethyl)benzohydrazide | HCID 520662 | — |
반응 단계
More specifically, to prepare ST-246 monohydrate, Form I, cycloheptatriene is reacted with maleic anhydride in the presence of toluene to yield the major product, endo isomer. The exo isomer is further produced from about 7% to 0.6% by crystallization from toluene/heptane. Further, hydrazine in the anhydrous or hydrate form is reacted with Methyl 4-(trifluoromethyl)benzoate in the presence of isopropanol to yield (4-(trifluoromethyl)-benzhydrazide. The product is then crystallized from isopropanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09339466B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-5de744a66bb9456fb5708ea16b86e461 |
| 출처 메모 | uspto-grants-2016_05 |