Imidazole → tert-Butyl(4-chlorobutoxy)dimethylsilane
반응식
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][OH:6].N1C=CN=C1.[CH3:12][C:13]([Si:16](Cl)([CH3:18])[CH3:17])([CH3:15])[CH3:14]>C(Cl)Cl>[C:13]([Si:16]([O:6][CH2:5][CH2:4][CH2:3][CH2:2][Cl:1])([CH3:18])[CH3:17])([CH3:15])([CH3:14])[CH3:12]참가 물질
5
실험 절차
Compound 7-a, 4-chloro-1-butanol, (CAS 928-51-8) (100 g, 920 mmol) was dissolved in CH2Cl2 (1000 mL) at room temperature. Imidazole (CAS 288-32-4) (81.5, 1200 mmol) and TBDMS-Cl (CAS 18162-48-6) (152 g, 1010 mmol) was added at 0° C. The mixture was stirred for 4 h at rt. The mixture was filtered off. The filtrate was washed with 10% aqueous HCl-solution and brine. After evaporation of the filtrate, we get the product 7-c as a clear oil (100 g, 50%).
후처리
- filtrationThe mixture was filtered off
- washThe filtrate was washed with 10% aqueous HCl-solution and brine
- customAfter evaporation of the filtrate, we
출처 및 근거
- ORD 기록
- ord-73994b508e35494c8ce36831a70af501
- 출처 데이터셋
- uspto-grants-2016_05
- 특허 번호
- US09339494B2
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