2-Chloroethyl isocyanate → HCID 14625246, 화합물

HRID 523585노트

반응식

HRID 523585 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([Cl:8])[CH:3]=1.[Cl:9][CH2:10][CH2:11][N:12]=[C:13]=[O:14]>C1(C)C=CC=CC=1>[Cl:9][CH2:10][CH2:11][NH:12][C:13]([NH:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([Cl:8])[CH:3]=1)=[O:14]

참가 물질

4

반응물 2

HCID 160352-Chloroethyl isocyanateHCID 844322-Chloropyridin-4-amine

생성물 1

HCID 14625246HCID 14625246, 화합물수율 61%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Using analogous reagents and reaction conditions as described in Example 1 above, 4-amino-2-chloro pyridine (3.0 g, 23.33 mmol) in toluene (30 mL) was reacted with 1-chloro-2-isocyanatoethane (3.69 g, 350 mmol) and purified by column chromatography on silica gel (1.5% methanol in DCM) to afford 3.3 g of the product (61% yield).

후처리

  1. customreagents and reaction conditions
  2. custompurified by column chromatography on silica gel (1.5% methanol in DCM)

출처 및 근거

ORD 기록
ord-37ef734df1844a4b80cc3454fe7e8364
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09339501B2

반응 노트

불러오는 중…