Diisopropylamine → HCID 68899458, 화합물

HRID 523587노트

반응식

HRID 523587 반응식
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[C:8]1(=[O:12])[CH2:11][CH2:10][CH2:9]1.C([Li])CCC.C(NC(C)C)(C)C>C1COCC1>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1([OH:12])[CH2:11][CH2:10][CH2:9]1

참가 물질

6

반응물 4

HCID 7912DiisopropylamineHCID 122863-BromopyridineHCID 14496CyclobutanoneHCID 178418339Butyllithium

생성물 1

HCID 68899458HCID 68899458, 화합물수율 55.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

3-bromopyridine (1 g, 6.329 mmol) was reacted with cylcobutanone (0.93 mL, 6.369 mmol), n-butyl lithium (4.02 mL, 7.64 mmol) and diisopropyl amine (0.99 mL, 7.005 mmol) in dry THF to afford the crude product. Purification by column chromatography on silica gel (40% ethyl acetate in hexane) afforded 802 mg of the product (55% yield). LCMS Purity: 79%, m/z=227.9 (M+1)

후처리

  1. customto afford the crude product
  2. customPurification by column chromatography on silica gel (40% ethyl acetate in hexane)

출처 및 근거

ORD 기록
ord-b19ebe027a2343b88a28a1689e7387cc
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09339501B2

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