Ethyl Acetate → HCID 70981944, 화합물

HRID 523591노트

반응식

HRID 523591 반응식
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[CH2:12][CH2:11][CH2:10][CH:9]=1.C(OCC)(=O)C>C1(C)C=CC=CC=1.CCCCCC.[Pt]=O>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1

참가 물질

6

반응물 2

HCID 8857Ethyl AcetateHCID 709821203-Bromo-4-cyclopent-1-enyl-pyridine

생성물 1

HCID 70981944HCID 70981944, 화합물수율 71%

시약·촉매·용매 3

HCID 82844Platinum oxide (PtO)촉매HCID 1140Toluene용매HCID 8058Hexane용매

실험 절차

Platinum oxide (20 mg) was added to a mixture of 3-bromo-4-cyclopent-1-enyl-pyridine (I-34b: 140 mg, 0.622 mmol) in toluene (5 mL) and stirred overnight under hydrogen atmosphere. The reaction was monitored by TLC (20% ethyl acetate in hexane). The reaction mixture was filtered through celite pad and washed with toluene and concentrated to afford crude product. Purification by column chromatography (8% ethyl acetate in hexane) afforded 98 mg of the product (71% yield).

후처리

  1. filtrationThe reaction mixture was filtered through celite pad
  2. washwashed with toluene
  3. concentrationconcentrated
  4. customto afford crude product
  5. customPurification by column chromatography (8% ethyl acetate in hexane)

출처 및 근거

ORD 기록
ord-d3eeadd28e1747978832e2646d230272
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09339501B2

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