3-(Trifluoromethyl)aniline → 3-(2-Chloroethyl)-1-[3-(trifluoromethyl)phenyl]urea
반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([NH2:9])[CH:6]=[CH:7][CH:8]=1.[Cl:12][CH2:13][CH2:14][N:15]=[C:16]=[O:17]>C1(C)C=CC=CC=1>[Cl:12][CH2:13][CH2:14][NH:15][C:16]([NH:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:4]=1)=[O:17]참가 물질
4
실험 절차
Using analogous reagents and reaction conditions as described in Example 1 above, 3-trifluoromethyl-phenylamine (2.0 g, 12.412 mmol) in toluene (20 mL) was reacted with 1-chloro-2-isocyanatoethane (1.96 g, 18.618 mmol to give 3.2 g of pure product (96%)
후처리
- customreagents and reaction conditions
출처 및 근거
- ORD 기록
- ord-3a9ec8df79194f3d817f026af8253543
- 출처 데이터셋
- uspto-grants-2016_05
- 특허 번호
- US09339501B2
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