m-Chloroperbenzoic acid → 4-Cyclopropyl-3-iodopyridine 1-oxide
반응식
ClC1C=CC=C(C(OO)=[O:9])C=1.[CH:12]1([C:15]2[CH:20]=[CH:19][N:18]=[CH:17][C:16]=2[I:21])[CH2:14][CH2:13]1>C(Cl)Cl>[CH:12]1([C:15]2[CH:20]=[CH:19][N+:18]([O-:9])=[CH:17][C:16]=2[I:21])[CH2:14][CH2:13]1참가 물질
4
실험 절차
m-Chloroperbenzoic acid (408 mg, 2.36 mmol) was added to the solution of 4-cyclopropyl-3-iodopyridine (I-30a: 200 mg. 0.816 mmol) in DCM (10 mL) and the resulting mixture was stirred at room temperature for 3 hours. The reaction was monitored by TLC. The reaction mixture was quenched with ice and diluted with DCM. The organic layer was washed with dilute NaOH solution, water and brine solution, dried over sodium sulphate and concentrated to afford 200 mg of the product (94.7% yield).
후처리
- customThe reaction mixture was quenched with ice
- additiondiluted with DCM
- washThe organic layer was washed with dilute NaOH solution, water and brine solution
- dry with materialdried over sodium sulphate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-95ae64408357478ab735cab158160275
- 출처 데이터셋
- uspto-grants-2016_05
- 특허 번호
- US09339501B2
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