Toluene → Methyl 3-(4-methylphenyl)benzoate

HRID 5237

반응식

HRID 5237 반응식
I[C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].[C:12]1([CH3:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>IC1C=CC(C)=CC=1.[Cu]>[CH3:18][C:12]1[CH:17]=[CH:16][C:15]([C:2]2[CH:11]=[CH:10][CH:9]=[C:4]([C:5]([O:7][CH3:8])=[O:6])[CH:3]=2)=[CH:14][CH:13]=1

참가 물질

5

반응물 2

HCID 1140TolueneHCID 69258Methyl 3-iodobenzoate

생성물 1

HCID 1394187Methyl 3-(4-methylphenyl)benzoate수율 29%

시약·촉매·용매 2

HCID 23978Copper촉매HCID 122074-Iodotoluene용매

실험 절차

To a mixture of methyl 3-iodobenzoate (26.1 g) in 4-iodotoluene (21.9 g) was added copper powder (31.8 g) gradually at 180°-190° C. The mixture was then stirred for 6 hours at 200°-210° C. The reaction mixture was cooled to room temperature, to which was added toluene. Insoluble materials were filtered off, and the filtrate was concentrated to dryness. The residue was purified by column chromatography on silica gel to afford the title compound as a colorless oil (6.61 g, 29%).

후처리

  1. filtrationInsoluble materials were filtered off
  2. concentrationthe filtrate was concentrated to dryness
  3. customThe residue was purified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-2fe8b08f64c844be852d3e2cfd2c0a0e
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05243054

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