Toluene → Methyl 3-(4-methylphenyl)benzoate
반응식
I[C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].[C:12]1([CH3:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>IC1C=CC(C)=CC=1.[Cu]>[CH3:18][C:12]1[CH:17]=[CH:16][C:15]([C:2]2[CH:11]=[CH:10][CH:9]=[C:4]([C:5]([O:7][CH3:8])=[O:6])[CH:3]=2)=[CH:14][CH:13]=1참가 물질
5
실험 절차
To a mixture of methyl 3-iodobenzoate (26.1 g) in 4-iodotoluene (21.9 g) was added copper powder (31.8 g) gradually at 180°-190° C. The mixture was then stirred for 6 hours at 200°-210° C. The reaction mixture was cooled to room temperature, to which was added toluene. Insoluble materials were filtered off, and the filtrate was concentrated to dryness. The residue was purified by column chromatography on silica gel to afford the title compound as a colorless oil (6.61 g, 29%).
후처리
- filtrationInsoluble materials were filtered off
- concentrationthe filtrate was concentrated to dryness
- customThe residue was purified by column chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-2fe8b08f64c844be852d3e2cfd2c0a0e
- 출처 데이터셋
- uspto-grants-1993_09
- 특허 번호
- US05243054
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