Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(4-(Methylamino)-2-(methylthio)pyrimidin-5-yl)methanol → 4-(Methylamino)-2-(methylthio)pyrimidine-5-carbaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (4-(Methylamino)-2-(methylthio)pyrimidin-5-yl)methanol | HCID 10679092 | — |
| 촉매 | HCID 178418406 | HCID 178418406 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-(Methylamino)-2-(methylthio)pyrimidine-5-carbaldehyde | HCID 10607520 | 91.3% |
반응 단계
A suspension of (4-(methylamino)-2-(methylthio)pyrimidin-5-yl)methanol (3.1 g, 16.73 mmol) and manganese dioxide (7.27 g, 83.67 mmol) in DCM (40 mL) was stirred at room temperature for 12 hours. The resulting precipitate was filtered off, and the filtrate was concentrated to give 4-(methylamino)-2-(methylthio)pyrimidine-5-carbaldehyde (2.8 g, 91%) as a yellowish solid. MS (ES+) C7H9N3OS requires: 183. found: 184 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09340514B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-f9696f12e90840699875c79329e25ea9 |
| 출처 메모 | uspto-grants-2016_05 |