2-Amino-5-bromobenzenemethanol → 2-Amino-5-bromobenzaldehyde

HRID 524033

반응식

HRID 524033 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH2:9][OH:10]>C(Cl)Cl.O=[Mn]=O>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH:9]=[O:10]

참가 물질

4

반응물 1

HCID 110308742-Amino-5-bromobenzenemethanol

생성물 1

HCID 235104752-Amino-5-bromobenzaldehyde수율 81%

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6344Dichloromethane용매

실험 절차

A mixture of (2-amino-5-bromophenyl)methanol (10 g, 49.5 mmol) and MnO2 (25.8 g, 296.6 mmol) in CH2Cl2 (400 mL) was stirred at RT overnight. LCMS showed the reaction was completed. The solid was filtered off, and the filtrate was concentrated to give the title compound as a light yellow solid (8 g, 81%), which was directly used in next step without further purification. MS (ES+) C7H6BrNO requires: 199. found: 200, 202 [M+H]+.

후처리

  1. filtrationThe solid was filtered off
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-cce5a4d41af44cbe996d2618a96c8642
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09340514B2

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