(6-Chloro-4-(methylamino)pyridin-3-yl)methanol → 6-Chloro-4-(methylamino)nicotinaldehyde

HRID 524051

반응식

HRID 524051 반응식
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[C:4]([NH:10][CH3:11])[CH:3]=1>ClCCl.C1COCC1.[O-2].[Mn+4].[O-2]>[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][CH3:11])[C:5]([CH:8]=[O:9])=[CH:6][N:7]=1

참가 물질

5

반응물 1

HCID 51000240(6-Chloro-4-(methylamino)pyridin-3-yl)methanol

생성물 1

HCID 234345716-Chloro-4-(methylamino)nicotinaldehyde수율 87.8%

시약·촉매·용매 3

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of (6-chloro-4-(methylamino)pyridin-3-yl)methanol (4.2 g, 24.7 mmol) and manganese(IV) oxide (active, 25.8 g, 296.6 mmol) in dichloromethane (50 mL) and THF (50 mL) was stirred at RT overnight. LCMS showed the reaction was completed. The solid was filtered off, and the filtrate was concentrated to afford the title compound (3.7 g, crude) as a light yellow solid, which was directly used in the next step without further purification. MS (ES+) C7H7ClN2O requires: 170, 172. found: 171, 173 [M+H]+.

후처리

  1. filtrationThe solid was filtered off
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-91f62f4b2cc8480080b516bf35366868
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09340514B2

연결된 노트

불러오는 중…