Potassium Carbonate → 7-chloro-3-(3,5-dimethoxyphenyl)-1-methyl-1,6-naphthyridin-2(1H)-one

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	Methyl 3,5-dimethoxyphenylacetate	HCID 592191	—
반응물	6-Chloro-4-(methylamino)nicotinaldehyde	HCID 23434571	—
용매	Dimethylformamide	HCID 6228	—
생성물	7-chloro-3-(3,5-dimethoxyphenyl)-1-methyl-1,6-naphthyridin-2(1H)-one	HCID 86713576	80.8%

반응 조건

온도	105 °C

반응 단계

A mixture of 6-chloro-4-(methylamino)nicotinaldehyde (3.7 g, 21.7 mmol), methyl 2-(3,5-dimethoxyphenyl)acetate (4.5 g, 21.7 mmol) and potassium carbonate (9.0 g, 65.1 mmol) in N,N-dimethylformamide (30 mL) was heated at 105° C. for 5 h. LCMS showed the reaction was completed. The reaction was cooled to RT, quenched with water (200 mL), and filtered. The filtration cake was washed by petroleum ether (50 mL) and ethyl acetate (50 mL) to afford the title compound (5.8 g, 77%) as a yellow solid. MS (ES+) C18H19ClN2O3 requires: 346, 348. found: 347, 349 [M+H]+.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09340514B2
출처 데이터셋	uspto-grants-2016_05
ORD ID	ord-9cf9ea22fa634854a14f4dd1149174fa
출처 메모	uspto-grants-2016_05