Potassium Carbonate → 7-chloro-3-(3,5-dimethoxyphenyl)-1,8-dimethyl-1,6-naphthyridin-2(1H)-one

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	Methyl 3,5-dimethoxyphenylacetate	HCID 592191	—
반응물	6-Chloro-5-methyl-4-(methylamino)nicotinaldehyde	HCID 86713590	—
용매	Dimethylformamide	HCID 6228	—
생성물	7-chloro-3-(3,5-dimethoxyphenyl)-1,8-dimethyl-1,6-naphthyridin-2(1H)-one	HCID 86713591	95%

반응 조건

온도	105 °C

반응 단계

A mixture of 6-chloro-5-methyl-4-(methylamino)nicotinaldehyde (3.11 g, 16.8 mmol), methyl 2-(3,5-dimethoxyphenyl)acetate (4.25 g, 20.2 mmol) and potassium carbonate (2.8 g, 20.3 mmol) in N,N-dimethylformamide (100 mL) was stirred at 105° C. overnight. LCMS monitored the reaction was completed. The reaction mixture was cooled to RT and quenched by water. The precipitate was filtered and dried to get the title compound (5.5 g, crude) as a yellow solid. MS (ES+) C18H17ClN2O3 requires: 344, 346. found: 345, 347 [M+H]+.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09340514B2
출처 데이터셋	uspto-grants-2016_05
ORD ID	ord-b5d4d1ac9f7148c394290c2b063189d3
출처 메모	uspto-grants-2016_05