(2-Amino-4-methoxyphenyl)methanol → 2-Amino-4-methoxybenzaldehyde

HRID 524071

반응식

HRID 524071 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH2:10][OH:11]>ClCCl.[O-2].[Mn+2]>[NH2:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH:10]=[O:11]

참가 물질

4

반응물 1

HCID 45090899(2-Amino-4-methoxyphenyl)methanol

생성물 1

HCID 3235032-Amino-4-methoxybenzaldehyde수율 35.3%

시약·촉매·용매 2

HCID 160959Manganese oxide촉매HCID 6344Dichloromethane용매

실험 절차

A mixture of (2-amino-4-methoxyphenyl)methanol (20 g, 131.0 mmol) and manganese oxide (68 g, 786.0 mmol) in dichloromethane (300 mL) was stirred at RT overnight. LCMS showed the reaction was completed. The solid was filtered off, and the filtrate was concentrated. The residue was purified by silica gel chromatography (petroleum ether:ethyl acetate=6:1) to give the title compound (7 g, 35%) as a yellow solid. MS (ES+) C8H9NO2 requires: 151. found: 152 [M+H]+.

후처리

  1. filtrationThe solid was filtered off
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by silica gel chromatography (petroleum ether:ethyl acetate=6:1)

출처 및 근거

ORD 기록
ord-bb2fe668888f4e2689fdc4ae23fd131e
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09340514B2

연결된 노트

불러오는 중…