(2-Amino-5-bromo-3-fluorophenyl)methanol → 2-Amino-5-bromo-3-fluorobenzaldehyde

HRID 524078

반응식

HRID 524078 반응식
[NH2:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[CH2:10][OH:11]>ClCCl.[O-2].[Mn+2]>[NH2:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[CH:10]=[O:11]

참가 물질

4

반응물 1

HCID 54312525(2-Amino-5-bromo-3-fluorophenyl)methanol

생성물 1

HCID 542514502-Amino-5-bromo-3-fluorobenzaldehyde수율 85%

시약·촉매·용매 2

HCID 160959Manganese oxide촉매HCID 6344Dichloromethane용매

실험 절차

A mixture of (2-amino-5-bromo-3-fluorophenyl)methanol (13 g, 59.4 mmol) and manganese oxide (31 g, 356.4 mmol) in dichloromethane (400 mL) was stirred at RT overnight. TLC showed the starting material consumed completely. The solid was filtered off, and the filtrate was concentrated to give the title compound (11 g, 85%) as a light yellow solid, which was directly used in the next step without further purification.

후처리

  1. customconsumed completely
  2. filtrationThe solid was filtered off
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-b97d07b899804540be38b71d5efebbd3
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09340514B2

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