Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isoquinoline-1-carboxylic acid → 5-(3,4-Dimethoxyphenyl)-2-[1-(isoquinolin-1-ylcarbonyl)piperidin-4-yl]-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isoquinoline-1-carboxylic acid | HCID 68092 | — |
| 반응물 | 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride | HCID 66616406 | — |
| 생성물 | 5-(3,4-Dimethoxyphenyl)-2-[1-(isoquinolin-1-ylcarbonyl)piperidin-4-yl]-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one | HCID 46204655 | — |
반응 단계
The title compound is prepared analogously as described for GP2-WU2 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and isoquinoline-1-carboxylic acid as starting compounds. The crude product is purified by chromatography (silica gel and DCM/diethyl ether/methanol=5:5:1) to yield the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09340522B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-e381839f7e0a4628a331d1a40bd0c5d9 |
| 출처 메모 | uspto-grants-2016_05 |