Oxalyl chloride → 5-(Benzyloxy)-2-methylbenzoyl chloride

HRID 524320노트

반응식

HRID 524320 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH3:18])=[C:13]([CH:17]=1)[C:14](O)=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:22])=O>C(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH3:18])=[C:13]([CH:17]=1)[C:14]([Cl:22])=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 597600475-(Benzyloxy)-2-methylbenzoic acid2회

생성물 1

HCID 866574365-(Benzyloxy)-2-methylbenzoyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a mixture of 3.3 g 5-(benzyloxy)-2-methylbenzoic acid (compound F1) in 80 ml DCM are added 1.4 ml of oxaloylchloride, and the reaction is stirred at RT over night under a blanket of nitrogen. The solvent is removed under reduced pressure yielding the title compound, which was used without further purification.

후처리

  1. customThe solvent is removed under reduced pressure

출처 및 근거

ORD 기록
ord-2cfccea2aea04d5cab4c9ef385a394f4
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09340522B2

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