Methanesulfonyl chloride → N-[4-(3-morpholin-4-yl-quinoxalin-6-yl)-phenyl]-methanesulfonamide

HRID 524376노트

반응식

HRID 524376 반응식
[N:1]1([C:7]2[CH:8]=[N:9][C:10]3[C:15]([N:16]=2)=[CH:14][C:13]([C:17]2[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][CH:18]=2)=[CH:12][CH:11]=3)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH3:24][S:25](Cl)(=[O:27])=[O:26]>N1C=CC=CC=1>[N:1]1([C:7]2[CH:8]=[N:9][C:10]3[C:15]([N:16]=2)=[CH:14][C:13]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][S:25]([CH3:24])(=[O:27])=[O:26])=[CH:19][CH:18]=2)=[CH:12][CH:11]=3)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

참가 물질

4

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 670349784-(3-Morpholin-4-yl-quinoxalin-6-yl)-phenylamine

생성물 1

HCID 67035522N-[4-(3-morpholin-4-yl-quinoxalin-6-yl)-phenyl]-methanesulfonamide수율 56.6%

시약·촉매·용매 1

HCID 1049Pyridine용매2회

실험 절차

A mixture of 4-(3-morpholin-4-yl-quinoxalin-6-yl)-phenylamine [intermediate example 4.1] (100 mg) and pyridine (0.5 mL) was treated with a solution of methane sulfonyl chloride (75 mg, 0.65 mmol) in pyridine (0.6 mL) and stirred at room temperature overnight. The reaction was partitioned between dichloromethane and water, the phases separated and the organic layer concentrated in vacuo. The residue was triturated with dichloromethane and filtered to give the title compound (71 mg). UPLC-MS: RT=0.97 min; m/z (ES+) 385.19 [MH+]; required MW=384.46.

후처리

  1. customThe reaction was partitioned between dichloromethane and water
  2. customthe phases separated
  3. concentrationthe organic layer concentrated in vacuo
  4. customThe residue was triturated with dichloromethane
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-f7e53d73adde4720bcccd5ae72430ffb
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09340528B2

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