HCID 19963711, 화합물 → HCID 19963713, 화합물

HRID 52438노트

반응식

HRID 52438 반응식
[CH3:1][C:2]1([CH3:19])[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]#[C:13][Si](C)(C)C)[CH:10]=2)[NH:5][C:4](=[O:18])[CH2:3]1>CO>[CH3:1][C:2]1([CH3:19])[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]#[CH:13])[CH:10]=2)[NH:5][C:4](=[O:18])[CH2:3]1

참가 물질

3

반응물 1

HCID 19963711HCID 19963711, 화합물2회

생성물 1

HCID 19963713HCID 19963713, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 2.64 g (9.7 mmol) of 4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-6[(trimethylsilyl)ethynyl]quinoline (Compound 2) in 200 ml of methanol was added 0.269 g (1.95 mmol) of K2CO3The reaction was stirred at room temperature for 12 h. The reaction was then concentrated in vacuo and water was added to the residue. The aqueous layer was extracted with methylene chloride (2×). The organic layers were dried (MgSO4), filtered and concentrated in vacuo to give the title compound as a white solid.

후처리

  1. concentrationThe reaction was then concentrated in vacuo and water
  2. additionwas added to the residue
  3. extractionThe aqueous layer was extracted with methylene chloride (2×)
  4. dry with materialThe organic layers were dried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-30f595256a6247b692fae42f1712eea2
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05616712

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