Ethyl 2-(4-benzyloxyphenyl)-2-methylpropanoate → Ethyl 2-(4-hydroxyphenyl)-2-methylpropanoate

HRID 524409노트

반응식

HRID 524409 반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([CH3:22])([CH3:21])[C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:11][CH:10]=1)C1C=CC=CC=1>O.[Pd].C(OCC)(=O)C>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]([CH3:21])([CH3:22])[C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:13][CH:14]=1

참가 물질

5

반응물 1

HCID 69644592Ethyl 2-(4-benzyloxyphenyl)-2-methylpropanoate

생성물 1

HCID 21269145Ethyl 2-(4-hydroxyphenyl)-2-methylpropanoate수율 62.1%

시약·촉매·용매 3

HCID 962Water촉매HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

Under inert atmosphere, a round bottom flask was charged with ethyl 2-(4-benzyloxyphenyl)-2-methyl-propanoate (15 g, mmol) and ethyl acetate (200 mL). To above reaction mixture 2-3 drops of water was added followed by Pd/C. Reaction mixture allowed to stir and evacuated the flask until solvent begins to bubble and then carefully backfill with nitrogen gas (repeated twice). Nitrogen balloon was replaced by hydrogen bladder and flask was again evacuated and refilled with hydrogen (repeated twice). The reaction mixture thus maintained under hydrogen atmosphere was allowed to stir overnight at room temperature. The reaction mixture was filtered through cellite pad and the filtrate was concentrated under reduced pressure to afford 6.5 g of product.

후처리

  1. additionwas added
  2. customReaction mixture
  3. customevacuated the flask until solvent
  4. customto bubble
  5. customwas again evacuated
  6. additionrefilled with hydrogen (
  7. temperatureThe reaction mixture thus maintained under hydrogen atmosphere
  8. stirringto stir overnight at room temperature
  9. filtrationThe reaction mixture was filtered through cellite pad
  10. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-fdde32cfae14428f87c38f5a138ff54c
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09340506B2

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