Potassium Carbonate → 4,4-Dimethyl-2-iso-propoxy-3,4-dihydro-7-ethynylquinoline

HRID 52448노트

반응식

HRID 52448 반응식
[CH3:1][C:2]1([CH3:22])[C:11]2[C:6](=[CH:7][C:8]([C:12]#[C:13][Si](C)(C)C)=[CH:9][CH:10]=2)[NH:5][CH:4]([O:18][CH:19]([CH3:21])[CH3:20])[CH2:3]1.C(=O)([O-])[O-].[K+].[K+]>CO>[CH3:1][C:2]1([CH3:22])[C:11]2[C:6](=[CH:7][C:8]([C:12]#[CH:13])=[CH:9][CH:10]=2)[N:5]=[C:4]([O:18][CH:19]([CH3:20])[CH3:21])[CH2:3]1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 199637264,4-Dimethyl-2-iso-propoxy-1,2,3,4-tetrahydro-7-[(trimethylsilyl)ethynyl]quinoline2회

생성물 1

HCID 199637244,4-Dimethyl-2-iso-propoxy-3,4-dihydro-7-ethynylquinoline

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 0.14 g (0.45 mmol) of 4,4-dimethyl-2-iso-propoxy-1,2,3,4-tetrahydro-7-[(trimethylsilyl)ethynyl]quinoline (Compound 26) in 2.5 ml of methanol was added 0.10 g (0.72 mmol) of potassium carbonate. The reaction mixture was then stirred at room temperature for 2.5 h. The reaction mixture was then concentrated in vacuo and the resulting oil was dissolved in water and extracted with methylene chloride (2×). The organic layers were dried (MgSO4), filtered and concentrated in vacuo to give the title compound as an oil. This compound was used for the next reaction without further purification.

후처리

  1. concentrationThe reaction mixture was then concentrated in vacuo
  2. dissolutionthe resulting oil was dissolved in water
  3. extractionextracted with methylene chloride (2×)
  4. dry with materialThe organic layers were dried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-3b49daf3eaa64ffa90521ef7140c9676
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05616712

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