Formic Acid → N-(4-chlorophenyl)formamide

HRID 524482

반응식

HRID 524482 반응식
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[CH:9](O)=[O:10]>>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH:9]=[O:10])=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 284Formic AcidHCID 78124-Chloroaniline

생성물 1

HCID 17475N-(4-chlorophenyl)formamide수율 97%

실험 절차

4-Chloroaniline (15 g, 117 mmol) and formic acid (25 mL, 663 mmol) were heated to reflux for 2 hours. The mixture was concentrated in vacuo. Saturated aqueous sodium hydrogen carbonate was added and the aqueous phase was extracted twice with ethyl acetate. The combined organic phases were dried over magnesium sulphate, filtered and concentrated in vacuo to give N-(4-chloro-phenyl)-formamide (17.6 g, 97%) as a grey crystalline compound.

후처리

  1. temperatureto reflux for 2 hours
  2. concentrationThe mixture was concentrated in vacuo
  3. additionSaturated aqueous sodium hydrogen carbonate was added
  4. extractionthe aqueous phase was extracted twice with ethyl acetate
  5. dry with materialThe combined organic phases were dried over magnesium sulphate
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-5a97fcde4bcd4caa9f3db83e83a390e0
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09340544B2

연결된 노트

불러오는 중…