Ammonium Chloride → 5-Methyl-1,3,4-thiadiazole-2-carboximidamide hydrochloride

반응식

[CH3:1][C:2]1[S:6][C:5]([C:7]#[N:8])=[N:4][N:3]=1.C[O-].[Na+].[Cl-:12].[NH4+:13]>>[ClH:12].[CH3:1][C:2]1[S:6][C:5]([C:7](=[NH:13])[NH2:8])=[N:4][N:3]=1

참가 물질

반응물 3

HCID 25517Ammonium Chloride

HCID 10942334Sodium Methoxide

HCID 185439255-Methyl-1,3,4-thiadiazole-2-carbonitrile

생성물 1

HCID 900429855-Methyl-1,3,4-thiadiazole-2-carboximidamide hydrochloride수율 70%

실험 절차

5-methyl-1,3,4-thiadiazole-2-carbonitrile (1.25 g, 10 mmol) was reacted with sodium methoxide (0.54 g, 10 mmol) and ammonium chloride (0.64 g, 12 mmol) according to the procedure as described in Example 61, Step B to give the title compound as a yellowish solid (1.25 g, 70%). The compound was characterized by the following spectroscopic data:

출처 및 근거

ORD 기록: ord-9f7847bf72fa422d8321bbcd3833e6bb
출처 데이터셋: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09340538B2

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