Ammonium Chloride → 1-methyl-1H-1,2,4-triazole-3-carboximidamide hydrochloride

HRID 524692노트

반응식

[CH3:1][N:2]1[CH:6]=[N:5][C:4]([C:7]#[N:8])=[N:3]1.C[O-].[Na+].[Cl-:12].[NH4+:13]>>[ClH:12].[CH3:1][N:2]1[CH:6]=[N:5][C:4]([C:7](=[NH:13])[NH2:8])=[N:3]1

참가 물질

반응물 3

HCID 25517Ammonium Chloride

HCID 10942334Sodium Methoxide

HCID 607103171-methyl-1H-1,2,4-triazole-3-carbonitrile

생성물 1

HCID 900441211-methyl-1H-1,2,4-triazole-3-carboximidamide hydrochloride수율 78.8%

실험 절차

1-methyl-1H-1,2,4-triazole-3-carbonitrile (20 g, 185 mmol) was reacted with sodium methoxide (14 g, 295 mmol) and ammonium chloride (14.8 g, 277.5 mmol) according to the procedure as described in Example 61, Step B to give the title compound as a white solid (23.44 g, 78.8%). The compound was characterized by the following spectroscopic data:

출처 및 근거

ORD 기록: ord-ca98bc871af843d284830ebbfdef4d73
출처 데이터셋: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09340538B2

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