Ammonium Chloride → Methyl 2-(3-carbamimidoyl-1H-1,2,4-triazol-1-yl)acetate hydrochloride

반응식

[C:1]([C:3]1[N:7]=[CH:6][N:5]([CH2:8][C:9]([O:11][CH2:12]C)=[O:10])[N:4]=1)#[N:2].C[O-].[Na+].[Cl-:17].[NH4+:18]>>[ClH:17].[C:1]([C:3]1[N:7]=[CH:6][N:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[N:4]=1)(=[NH:2])[NH2:18]

참가 물질

반응물 3

HCID 25517Ammonium Chloride

HCID 10942334Sodium Methoxide

HCID 60710264ethyl 2-(3-cyano-1H-1,2,4-triazol-1-yl)acetate

생성물 1

HCID 90042811Methyl 2-(3-carbamimidoyl-1H-1,2,4-triazol-1-yl)acetate hydrochloride수율 55%

실험 절차

Ethyl 2-(3-cyano-1H-1,2,4-triazol-1-yl)acetate (2 g, 11.2 mmol) was reacted with sodium methoxide (0.85 g, 15.68 mmol) and ammonium chloride (0.89 g, 16.8 mmol) according to the procedure as described in Example 61, Step B to give the title compound as a white solid (1.35 g, 55%). The compound was characterized by the following spectroscopic data:

출처 및 근거

ORD 기록: ord-002c5003137c447c984d7d10eac4f92b
출처 데이터셋: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09340538B2

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