Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetoacetate → Ethyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(pyrazin-2-yl)-1,4-dihydropyrimidine-5-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetoacetate | HCID 8868 | — |
| 반응물 | 2-Chloro-4-fluorobenzaldehyde | HCID 145024 | — |
| 반응물 | Pyrazine-2-carboxamidine hydrochloride | HCID 470895 | — |
| 생성물 | Ethyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(pyrazin-2-yl)-1,4-dihydropyrimidine-5-carboxylate | HCID 118107549 | 41% |
반응 단계
Pyrazine-2-carboximidamide hydrochloride (5 g, 31.5 mmol) was reacted with 2-chloro-4-fluorobenzaldehyde (5 g, 31.5 mmol) and ethyl 3-oxobutanoate (4.1 g, 31.5 mmol) according to the procedure as described in Example 1, Step A to give the title compound as a yellow solid (4.84 g, 41%). The compound was characterized by the following spectroscopic data:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09340538B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-2df5724b920746949c2d5f84a29dc7d2 |
| 출처 메모 | uspto-grants-2016_05 |