Ammonium Chloride → 5-Methoxythiazole-2-carboximidamide hydrochloride

HRID 524803노트

반응식

[CH3:1][O:2][C:3]1[S:7][C:6]([C:8]#[N:9])=[N:5][CH:4]=1.C[O-].[Na+].[Cl-:13].[NH4+:14]>>[ClH:13].[CH3:1][O:2][C:3]1[S:7][C:6]([C:8](=[NH:14])[NH2:9])=[N:5][CH:4]=1

참가 물질

반응물 3

HCID 25517Ammonium Chloride

HCID 10942334Sodium Methoxide

HCID 900443835-Methoxythiazole-2-carbonitrile

생성물 1

HCID 900443915-Methoxythiazole-2-carboximidamide hydrochloride수율 50.1%

실험 절차

5-methoxythiazole-2-carbonitrile (0.74 g, 5.26 mmol) was reacted with sodium methoxide (0.28 g, 5.26 mmol) and ammonium chloride (0.6 g, 11 mmol) according to the procedure as described in Example 61, Step B to give the title compound as a white solid (0.51 g, 50%). The compound was characterized by the following spectroscopic data:

출처 및 근거

ORD 기록: ord-0acb2cb2b6f34530ada9a9277acb8d23
출처 데이터셋: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09340538B2

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