HCID 86720950, 화합물 → HCID 86720951, 화합물
반응식
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[C:13]([N+:14]([O-])=O)=[CH:12][N:11]=[C:10]([NH2:17])[CH:9]=2)[CH2:4][CH2:3]1>CCOC(C)=O.CCO.[Pd]>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[C:13]([NH2:14])=[CH:12][N:11]=[C:10]([NH2:17])[CH:9]=2)[CH2:4][CH2:3]1참가 물질
5
실험 절차
Pd on C, (10%, wet, Degussa) (140 mg, 0.1316 mmol) was added to a stirred solution of 4-(4-methylpiperazin-1-yl)-5-nitro-pyridin-2-amine (355 mg, 1.496 mmol) in a mixture of EtOAc (5 mL) and EtOH (50 mL). The reaction was placed under an atmosphere of hydrogen and stirred at ambient temperature for 16 hours. The catalyst was removed by filtration through a pad of celite and the filtrate concentrated in vacuo to give 4-(4-methylpiperazin-1-yl)pyridine-2,5-diamine as a brown solid (291 mg, 94% Yield). MS (ES+) 208.1.
후처리
- customThe catalyst was removed by filtration through a pad of celite
- concentrationthe filtrate concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-d9f536402f4643b790aa49aadf6de840
- 출처 데이터셋
- uspto-grants-2016_05
- 특허 번호
- US09340546B2
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