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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 525010생성일: 2026년 10월 25일

2-Pyridinemethanamine → (S)-tert-Butyl 1-(3-bromo-2-(pyridin-2-ylmethylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate

https://huagongshe.com/reaction/525010

반응식

참여 물질

역할이름HCID투입량
반응물2-PyridinemethanamineHCID 19509—
반응물(S)-Methyl 3-bromo-1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylateHCID 86722018—
생성물(S)-tert-Butyl 1-(3-bromo-2-(pyridin-2-ylmethylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamateHCID 86722030—

반응 단계

Same procedure as described in preparation 133a was used from (S)-methyl 3-bromo-1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate (374 mg, 0.96 mmols) and pyridine-2-ylmethanamine (0.30 ml, 2.87 mmols). After reverse phase chromatography the title compound was obtained (74 mg, 17%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09340547B2
출처 데이터셋uspto-grants-2016_05
ORD IDord-7924540c81e04da7a4c919b93d5390ce
출처 메모uspto-grants-2016_05