Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-6-(trifluoromethyl)pyridine → (S)-Benzyl 1-(3-bromo-2-(6-(trifluoromethyl)pyridin-2-ylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-6-(trifluoromethyl)pyridine | HCID 821024 | — |
| 반응물 | (S)-Methyl 1-(2-(benzyloxycarbonylamino)propanamido)-3-Bromo-1H-Pyrrole-2-carboxylate | HCID 86722049 | — |
| 생성물 | (S)-Benzyl 1-(3-bromo-2-(6-(trifluoromethyl)pyridin-2-ylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate | HCID 86722053 | 51% |
반응 단계
The title compound was prepared from (S)-methyl 1-(2-(benzyloxycarbonylamino)propanamido)-3-bromo-1H-pyrrole-2-carboxylate (2.00 g, 4.7 mmol) and 6-(trifluoromethyl)pyridin-2-amine (3.00 g, 18.5 mmol) following the experimental procedure described in Preparation 44a. 1.32 g (51% yield) of the desired compound were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09340547B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-ed12ed702594484a830867559399ecc0 |
| 출처 메모 | uspto-grants-2016_05 |