O-Benzyl-N-(tert-butoxycarbonyl)-L-homoserine → (S)-Methyl 1-(4-(benzyloxy)-2-(tert-butoxycarbonylamino)butanamido)-3-bromo-1H-pyrrole-2-carboxylate

HRID 525041

반응식

HRID 525041 반응식
[NH2:1][N:2]1[CH:6]=[CH:5][C:4]([Br:7])=[C:3]1[C:8]([O:10][CH3:11])=[O:9].[CH2:12]([O:19][CH2:20][CH2:21][C@H:22]([NH:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[C:23](O)=[O:24])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([O:19][CH2:20][CH2:21][C@H:22]([NH:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[C:23]([NH:1][N:2]1[CH:6]=[CH:5][C:4]([Br:7])=[C:3]1[C:8]([O:10][CH3:11])=[O:9])=[O:24])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

참가 물질

3

반응물 2

HCID 15058464O-Benzyl-N-(tert-butoxycarbonyl)-L-homoserineHCID 70979762methyl 1-amino-3-bromo-1H-pyrrole-2-carboxylate

생성물 1

HCID 86722060(S)-Methyl 1-(4-(benzyloxy)-2-(tert-butoxycarbonylamino)butanamido)-3-bromo-1H-pyrrole-2-carboxylate수율 93%

실험 절차

The title compound was prepared from methyl 1-amino-3-bromo-1H-pyrrole-2-carboxylate (2.83 g, 12.9 mmol) and (S)-4-(benzyloxy)-2-(tert-butoxycarbonylamino)butanoic acid (4.0 g, 12.9 mmol) following the experimental procedure described in Preparation 73a. 6.12 g (93% yield) of the desired compound were obtained.

출처 및 근거

ORD 기록
ord-a80f5feec49146be99b70067b94a9468
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09340547B2

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