Benzenesulfonamide, 3-amino- → 9-Bromo-5-(m-sulfamoylphenylcarbamoylmethyl)-6,7-dihydro-1H, 5H-pyrido[1,2,3-de]quinoxaline-2,3-dione

HRID 52506

반응식

HRID 52506 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[CH2:16][CH2:15][CH:14]([CH2:17][C:18]([OH:20])=O)[N:6]3[C:7](=[O:13])[C:8](=[O:12])[NH:9][C:10]([CH:11]=1)=[C:5]23.[S:21]([C:25]1[CH:26]=[C:27]([CH:29]=[CH:30][CH:31]=1)[NH2:28])(=[O:24])(=[O:23])[NH2:22]>>[Br:1][C:2]1[CH:3]=[C:4]2[CH2:16][CH2:15][CH:14]([CH2:17][C:18](=[O:20])[NH:28][C:27]3[CH:29]=[CH:30][CH:31]=[C:25]([S:21](=[O:24])(=[O:23])[NH2:22])[CH:26]=3)[N:6]3[C:7](=[O:13])[C:8](=[O:12])[NH:9][C:10]([CH:11]=1)=[C:5]23

참가 물질

3

반응물 2

HCID 7377Benzenesulfonamide, 3-amino-HCID 104723389-bromo-5-carboxymethyl-6,7-dihydro-1H, 5 H-pyrido[1,2,3-de]quinoxaline-2,3-dione

생성물 1

HCID 544448559-Bromo-5-(m-sulfamoylphenylcarbamoylmethyl)-6,7-dihydro-1H, 5H-pyrido[1,2,3-de]quinoxaline-2,3-dione수율 85%

실험 절차

A procedure similar to that described in Example 51 was carried out with 9-bromo-5-carboxymethyl-6,7-dihydro-1H, 5H-pyrido[1,2,3-de]quinoxaline-2,3-dione (170 mg, 0.5 mmol) and m-sulfamoylaniline (100 mg, 0.58 mmol) to give 209 mg of the title compound (85%): mp>270° C.; 1H NMR (270 MHz, DMSO-d6) δ12.07 (s, 1H), 10.33 (s, 1H), 8.13 (s, 1H), 7.70~7.78 (m, 1H), 7.45~7.55 (m,2H), 7.24 (bs, 1H), 7.15 (bs, 1H), 5.15~5.28 (m, 1H), 3.06 (ddd, 1H, J=17.1, 13.5, 4.5 Hz), 2.83 (dm, 1H, J=16.8 Hz), 2.65 (dd, 1H, J=18, 13.5 Hz), 2.58 (dd, 1H, J=18, 5.4 Hz), 2.12 (dm, 1H, J=13.5 Hz), 1.80~1.97 (m, 1H).

출처 및 근거

ORD 기록
ord-35f68068ee784060ba0c6fb9113805bd
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05616586

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