Methanol → Methyl 6-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate

HRID 525468

반응식

HRID 525468 반응식
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([C:12]([OH:14])=[O:13])[CH2:6][CH2:5]2.[CH3:15]O.S(=O)(=O)(O)O>>[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([C:12]([O:14][CH3:15])=[O:13])[CH2:6][CH2:5]2

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 190700016-Hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

생성물 1

HCID 58055117Methyl 6-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate수율 100%

실험 절차

To a solution of 6-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid (0.5 g, 3 mmol) in methanol (6 mL, 200 mmol) was added sulfuric acid (0.05 g, 0.5 mmol) and stirred over weekend. After concentration, the residue was dissolved in EtOAc and washed with water, brine and dried over Na2SO4 to give the pure product as a white solid (0.55 g, 100%). LCMS: Rt=1.17 min, m/z=207.00 [M+], 100%.

후처리

  1. concentrationAfter concentration
  2. dissolutionthe residue was dissolved in EtOAc
  3. washwashed with water, brine
  4. dry with materialdried over Na2SO4

출처 및 근거

ORD 기록
ord-a7e6033a74cc4ee7948069f4f9150761
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09340527B2

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