Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → HCID 178469205, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| 반응물 | 4-Phenylcyclohexanol | HCID 79497 | — |
| 반응물 | Ethyl 1-((6-hydroxynaphthalen-2-yl)methyl)piperidine-4-carboxylate | HCID 68279222 | — |
| 생성물 | HCID 178469205 | HCID 178469205 | 50% |
반응 단계
A mixture of 1-(6-hydroxy-naphthalen-2-ylmethyl)-piperidine-4-carboxylic acid ethyl ester (0.400 g, 1.28 mmol), 4-phenyl-cyclohexanol (0.2479 g, 1.406 mmol) and triphenylphosphine (0.6695 g, 2.553 mmol) in toluene (5 mL, 40 mmol) was stirred for 20 min, then diisopropyl azodicarboxylate (0.32 mL, 1.5 mmol) was added dropwise at 0° C. The solution was stirred at reflux overnight. The reaction was added silica gel and the solvent was concentrated. The residue was purified with silica gel eluted with EtOAc in hexanes from 0 to 20% to give product as an oil (0.3 g, 50%). LCMS: Rt=1.75 min, m/z=472.45 [M+H].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09340527B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-5f1015eb4a024fe496a210a4adf75146 |
| 출처 메모 | uspto-grants-2016_05 |