Ammonia → (7-Bromoimidazo[1,2-A]pyridin-2-YL)methanamine

HRID 525555노트

반응식

HRID 525555 반응식
[Br:1][C:2]1[CH:7]=[CH:6][N:5]2[CH:8]=[C:9]([CH2:11]Cl)[N:10]=[C:4]2[CH:3]=1.[NH3:13]>CO>[Br:1][C:2]1[CH:7]=[CH:6][N:5]2[CH:8]=[C:9]([CH2:11][NH2:13])[N:10]=[C:4]2[CH:3]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 441183127-Bromo-2-chloromethylimidazo[1,2-a]pyridine

생성물 1

HCID 72209893(7-Bromoimidazo[1,2-A]pyridin-2-YL)methanamine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a stirred solution of 7-Bromo-2-chloromethyl-imidazo[1,2-a]pyridine (0.325 g, 1.326 mmol) in methanol (5 mL), NH3 gas is purged at 0° C. for 30 minutes. The reaction is allowed to stir at room temperature for 16 hours. The solvent is concentrated to afford the title compound (0.315 g). 1H-NMR (400 MHz, DMSO-d6) δ: 4.15 (s, 2H), 7.12-7.15 (dd J1=1.96 Hz, J2=7.24 Hz, 1H), 7.90 (s, 1H), 8.03 (s, 1H), 8.32 (bs, 2H), 8.61 (d, J=7.2 Hz, 1H). LC-MS (m/z): [M+H]=225.9.

후처리

  1. concentrationThe solvent is concentrated

출처 및 근거

ORD 기록
ord-0bc36cd68e5e4ab38f0235088538b16f
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09340564B2

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