Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 1,2-Benzenedimethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | 1,4-Benzenedimethanol | HCID 11506 | — |
| 반응물 | Isobutyryl chloride | HCID 62325 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Sodium chloride; water | HCID 57417360 | — |
| 생성물 | 1,2-Benzenedimethanol | HCID 69153 | 212.9% |
반응 단계
1,4-xylylene glycol (5 g, 0.0306 mol), pyridine (5.7 g, 0.072 mol), and catalyst DMAP (ca. 100 mg) in a solution of dichloromethane (ca. 25 ml) were added to a flask. Isobutyryl chloride (7.71 g, 0.072 mol) was then added to the solution drop wise. The mixture was stirred overnight. 1M HCL brine was used to wash the mixture. The organic layer was dried over MgSO4 and concentrated in vacuo to afford a clear oil as the product (9 g). Its purity was ascertained using 1H NMR (300 MHz in CDCL3): δ 7.34 (s, 4H), 5.11 (s, 4H), 2.60 (sept, 2H), 1.19 (d, 12H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09340658B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-709dbd25a92f41c0adc014e5dfe877dd |
| 출처 메모 | uspto-grants-2016_05 |