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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 525675생성일: 2026년 10월 25일

2-(Methylamino)ethanol → 5-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-((2-hydroxyethyl)(methyl)amino)nicotinamide

https://huagongshe.com/reaction/525675

반응식

참여 물질

역할이름HCID투입량
반응물2-(Methylamino)ethanolHCID 8016—
반응물5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamideHCID 72546089—
생성물5-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-((2-hydroxyethyl)(methyl)amino)nicotinamideHCID 89906702—

반응 단계

The title compound was prepared in an analogous fashion to that described in Stage 22.1 using 5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamide (Stage 22.2) and 2-methylamino-ethanol to afford a white crystalline solid. HPLC (Condition 4) tR=5.72 min, UPLC-MS (Condition 3) tR=1.14 min, m/z=452.2 [M+H]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09340537B2
출처 데이터셋uspto-grants-2016_05
ORD IDord-89a2ad1b89894c47a8f025bc1e7fbe42
출처 메모uspto-grants-2016_05