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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 525677생성일: 2026년 10월 26일

2-(Ethylamino)ethanol → 5-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-(ethyl(2-hydroxyethyl)amino)nicotinamide

https://huagongshe.com/reaction/525677

반응식

참여 물질

역할이름HCID투입량
반응물2-(Ethylamino)ethanolHCID 8072—
반응물5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamideHCID 72546089—
생성물5-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-(ethyl(2-hydroxyethyl)amino)nicotinamideHCID 89906841—

반응 단계

The title compound was prepared in an analogous fashion to that described in Stage 22.1 using 5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamide (Stage 22.2) and 2-ethylamino-ethanol to afford an off-white crystalline solid. (Reaction Time was 10 h). HPLC (Condition 4) tR=6.1 min, UPLC-MS (Condition 3) tR=1.21 min, m/z=466.2 [M+H]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09340537B2
출처 데이터셋uspto-grants-2016_05
ORD IDord-d6ba9d57208c438db20c2b19e121365b
출처 메모uspto-grants-2016_05