1,4-Dideoxy-1,4-iminothreitol → 3-Bromo-N-(4-(chlorodifluoromethoxy)phenyl)-4-((3 S,4S)-3,4-dihydroxypyrrolidin-1-yl)benzamide

참여 물질

반응 단계

The title compound was prepared in an analogous fashion to that described in Example 1 using 3-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-4-fluorobenzamide (Stage 76.2) and (3S,4S)-pyrrolidine-3,4-diol. The crude product was purified by flash chromatography (Silica gel column, 12 g, n-hexane/EtOAc 10% to 100% EtOAc) to give the title product as a white solid. UPLC-MS (Condition 8) tR=1.02 min, m/z=477.1/478.9 [M+H]+.

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