Phenylacetic Acid → (R)-N5-(Amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl]-N2-(phenylacetyl)-ornithinamide

HRID 52586

반응식

HRID 52586 반응식
[NH2:1][C:2](=[N:20][N+:21]([O-:23])=[O:22])[NH:3][CH2:4][CH2:5][CH2:6][C@H:7]([C:9]([NH:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1)=[O:10])[NH2:8].[C:24]1([CH2:30][C:31](O)=[O:32])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>>[NH2:1][C:2](=[N:20][N+:21]([O-:23])=[O:22])[NH:3][CH2:4][CH2:5][CH2:6][C@H:7]([C:9]([NH:11][CH2:12][C:13]1[CH:14]=[CH:15][C:16]([OH:19])=[CH:17][CH:18]=1)=[O:10])[NH:8][C:31](=[O:32])[CH2:30][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

참가 물질

4

반응물 3

HCID 999Phenylacetic AcidHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 136381090(R)-N5-[amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl)-ornithinamide

생성물 1

HCID 136381102(R)-N5-(Amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl]-N2-(phenylacetyl)-ornithinamide수율 61%

실험 절차

Prepared analogously to Example 5f) from (R)-N5 -[amino (nitroimino) methyl]-N-[(4-hydroxyphenyl) methyl]ornithinamide, phenylacetic acid and TBTU in a yield of 61% of theory. It was further processed without purification.

후처리

  1. customIt was further processed without purification

출처 및 근거

ORD 기록
ord-48263591402d49cfbc2c7df15a519c5e
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05616620

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