Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Valproic Acid → (R)-N5-[Amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl]-N2-(1-oxo-2-propylpentyl)-ornithinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Valproic Acid | HCID 3121 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 반응물 | (R)-N5-[amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl)-ornithinamide | HCID 136381090 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (R)-N5-[Amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl]-N2-(1-oxo-2-propylpentyl)-ornithinamide | HCID 136381110 | 65% |
반응 단계
Prepared analogously to Example 5d), but using tetrahydrofuran instead of acetonitrile, from (R)-N5 -[amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl]-ornithinamide, 2-propyl-pentanoic acid and TBTU in a yield of 65% of theory. Colourless crystalline substance which was further processed without purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05616620 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-6015da7a28fd4a88b0e39061f1a3dbc5 |
| 출처 메모 | uspto-grants-1997_04 |