Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → 2,2-Diphenylethylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-[[[(2,2-Diphenylethyl)amino]carbonyl]amino]benzenemethylamine | HCID 18975927 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2,2-Diphenylethylamine | HCID 77575 | — |
| 생성물 | 4-Cyanophenyl isocyanate | HCID 170380 | — |
| 생성물 | 4-cyanophenyl-N'-(2,2-diphenylethyl)-urea | HCID 3849823 | — |
반응 단계
Prepared, analogously to Example 13a) but using dichloromethane as solvent instead of tetrahydrofuran and without using triethylamine, from 4-[[[(2,2-diphenylethyl)amino]carbonyl]amino]benzenemethylamine (mp.: 161°-163° C.; obtained from 4-cyanophenylisocyanate and 2,2-diphenylethylamine via N-(4-cyanophenyl-N'-(2,2-diphenylethyl)-urea, mp.: 235°-237° C., and finally by catalytic hydrogenation in the presence of Raney nickel and ammonia), (R)-N5 -[amino(nitroimino)methyl]-N2 -(diphenylacetyl)-ornithine, DCC and HOBt in a yield of 48% of theory.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05616620 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-3c374c14aa324310b266ecde97c37001 |
| 출처 메모 | uspto-grants-1997_04 |